|
|
|
| The mediating role of suicidal ideation between depression severity and cerebral blood flow changes in college students： Evidence from fNIRS |
| ZHANG Yan1, LIU Guohua1,2, HOU Yan1,3, CAO Xiaochen1, XIAO Qiang4, ZHENG Minxiao1,5 |
1 School of Education, Huazhong University of Science and Technology, Wuhan 430074;
2 Mental Health Education and Counseling Center, Guangdong Ocean University, Zhanjiang 524088;
3 Mental Health Education and Counseling Center for Uncversity Students at Hubei Minzu University, Enshi 445000;
4 Department of Neurology, Huazhong University of Science and Technology Hospital, Wuhan 430074;
5 School of Education, Jianghan University, Wuhan 430056 |
|
|
|
|
Abstract To investigate the mediating effect of suicidal ideation on depression and cerebral hemodynamic changes, 92 college students completed the hospital anxiety and depression scale and the suicidal ideation scale, and then functional near-infrared brain imaging was used to detect the changes of cerebral blood flow in the participants during the verbal fluency task. Results showed that the mean oxygenated hemoglobin in left supplementary motor area of depressed college students was significantly lower than that in healthy group. Suicidal ideation played a complete mediating role between the depression and the mean oxygenated hemoglobin concentration in channel 52 of the supplementary motor area. The results showed that the prefrontal lobe of depressed college students has functional impairment, and depression can affect the changes of cerebral blood flow in the prefrontal lobe through suicidal ideation, which suggested that suicidal ideation should be paid attention to in treatment of depression.
|
|
|
|
|
|
[1] 郭素然. (2021). 大学生睡眠质量对自杀意念的影响:抑郁和自尊的作用.心理研究, 14(05), 464-472.
[2] 石伟静, 穆敬平, 廖恒, 王熙, 刘丽珠, 郭俐宏. (2023). 近红外光谱成像技术在抑郁症中的研究进展.精神医学杂志, 36(03), 316-321.
[3] 夏朝云, 王东波, 吴素琴, 叶剑辉. (2002). 自杀意念自评量表的初步制定.临床精神医学杂志, (02), 100-102.
[4] 张福旭, 魏燕燕, 陈琪, 屠莉, 刘婉莹, 张天宏, 刘晓华. (2020). 重性抑郁障碍患者言语流畅性任务的脑血流动力学特征研究.中国神经精神疾病杂志, 46(10), 587-591.
[5] 张国华, 许明智, 金海燕. (2006). 医院焦虑抑郁量表的因素结构研究.中国临床心理学杂志, (06), 591-592.
[6] 张赫男, 边越然, 王桂香, 曹佳丽, 王翠红, 王午阳, 巴图, 张昊新, 张妍, 任虹霖. (2022). 抑郁患者药物干预的功能性近红外光谱成像研究.心理学进展, 12(9), 3284-3292.
[7] 张萍, 赵参参, 李鹏, 张文海, 魏青, 刘强, 李红. (2017). 青少年抑郁的心理影响因素及其神经机制.心理研究, 10(01), 78-83.
[8] Akiyama T., Koeda M., Okubo Y., & Kimura M. (2018). Hypofunction of left dorsolateral prefrontal cortex in depression during verbal fluency task: A multi-channel near-infrared spectroscopy study.Journal of Affective Disorders, 231, 83-90.
[9] Baik S. Y., Kim J., Choi J., Baek J. Y., Park Y., Kim Y., Jung M., & Lee S. (2019). Prefrontal asymmetry during cognitive tasks and its relationship with suicide ideation in major depressive disorder: An fNIRS study.Diagnostics, 9(4), 15.
[10] Exner C., Lange C., & Irle E. (2009). Impaired implicit learning and reduced pre-supplementary motor cortex size in early-onset major depression with melancholic features.Journal of Affective Disorders, 119(1-3), 156-162.
[11] Franklin J. C., Ribeiro J. D., Fox K. R., Bentley K. H., Kleiman E. M., Huang X., Musacchio K. M., Jaroszewski A. C., Chang B. P., & Nock M. K. (2017). Risk factors for suicidal thoughts and behaviors: A meta-analysis of 50 years of research.Psychological Bulletin, 143(2), 187-232.
[12] Gilbert, S. J., & Burgess, P. W. (2008). Executive function.Current Biology, 18(3), 110-114.
[13] Gilman S. E., Sucha E., Kingsbury M., Horton N. J., Murphy J. M., & Colman I. (2017). Depression and mortality in a longitudinal study: 1952-2011.Canadian Medical Association Journal, 189(42), E1304-E1310.
[14] Hawton K., Casa?as I Comabella C., Haw C., & Saunders K. (2013). Risk factors for suicide in individuals with depression: A systematic review.Journal of Affective Disorders, 147(1-3), 17-28.
[15] Hayes, A. F. (2017). Introduction to mediation, moderation, and conditional process analysis: A regression-based approach. Guilford publications.
[16] Herrmann M. J., Ehlis A. C., & Fallgatter A. J. (2004). Bilaterally reduced frontal activation during a verbal fluency task in depressed patients as measured by near-infrared spectroscopy.The Journal of Neuropsychiatry and Clinical Neurosciences, 16(2), 170-175.
[17] Ho C., Lim L., Lim A. Q., Chan N., Tan R. S., Lee S. H., & Ho R. (2020). Diagnostic and predictive applications of functional near-infrared spectroscopy for major depressive disorder: A systematic review.Frontiers in Psychiatry, 11, 378.
[18] Husain S. F., Wang N., McIntyre R. S., Tran B. X., Nguyen T. P., Vu L. G., Vu G. T., Ho R. C., & Ho C. S. (2023). Functional near-infrared spectroscopy of medical students answering various item types.Frontiers in Psychology, 14, 1178753.
[19] Kim H., Choi J., Jeong B., Fava M., Mischoulon D., Park M. J., Kim H. S., & Jeon H. J. (2022). Impaired oxygenation of the prefrontal cortex during verbal fluency task in young adults with major depressive disorder and suicidality: A functional near-infrared spectroscopy study.Frontiers in Psychiatry, 13, 9.
[20] Klonsky E. D., May A. M., & Saffer B. Y. (2016). Suicide, suicide attempts, and suicidal ideation. Annual Review of Clinical Psychology, 12, 307-330.
[21] Koenigs, M., & Grafman, J. (2009). The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex.Behavioural Brain Research, 201(2), 239-243.
[22] Lee Y. Q., Tay G. W. N., & Ho, C. S. H. (2021). Clinical utility of functional near-infrared spectroscopy for assessment and prediction of suicidality: A systematic review.Frontiers in Psychiatry, 12, 10.
[23] Liu S. T., Wu X., Wang N., Zhao Q. Q., Xiao L., Fang C. K., Yu Y., Lin D. M., & Zhang L. L. (2020). Serial multiple mediation of demoralization and depression in the relationship between hopelessness and suicidal ideation.Psycho-Oncology, 29(8), 1321-1328.
[24] Liu X., Cheng F., Hu S., Wang B., Hu C., Zhu Z., Zhuang W., Mei X., Li X., Zhou Q., Zhang W., Tang Y., & Zhou D. (2022). Cortical activation and functionalconnectivityduringtheverbalflue-ncytaskforadolescent-onsetdepression: Amulti-channel NIRS study.Journal of Psychiatric Research, 147, 254-261.
[25] Miller, E. K., & Cohen, J. D. (2001). An integrative theory of prefrontal cortex function.Annual Review of Neuroscience, 24, 167-202.
[26] Nachev P., Kennard C., & Husain M. (2008). Functional role of the supplementary and pre-supplementary motor areas.Nature Reviews Neuroscience, 9(11), 856-869.
[27] Noda T., Yoshida S., Matsuda T., Okamoto N., Sakamoto K., Koseki S., Numachi Y., Matsushima E., Kunugi H., & Higuchi T. (2012). Frontal and right temporal activations correlate negatively with depression severity during verbal fluency task: A multi-channel near-infrared spectroscopy study.Journal of Psychiatric Research, 46(7), 905-912.
[28] Okada G., Okamoto Y., Morinobu S., Yamawaki S., & Yokota N. (2003). Attenuated left prefrontal activation during a verbal fluency task in patients with depression.Neuropsychobiology, 47(1), 21-26.
[29] Pan Z. H., Park C., Brietzke E., Zuckerman H., Rong C., Mansur R. B., Fus D., Subramaniapillai M., Lee Y., & McIntyre R. S. (2019). Cognitive impairment in major depressive disorder.Cns Spectrums, 24(1), 22-29.
[30] Pinti P., Tachtsidis I., Hamilton A., Hirsch J., Aichelburg C., Gilbert S., & Burgess P. W. (2020). The present and future use of functional near-infrared spectroscopy (fNIRS) for cognitive neuroscience.Annals of the New York Academy of Sciences, 1464(1), 5-29.
[31] Pu S., Nakagome K., Yamada T., Yokoyama K., Matsumura H., Yamada S., Sugie T., Miura A., Mitani H., Iwata M., Nagata I., & Kaneko K. (2015). Suicidal ideation is associated with reduced prefrontal activation during a verbal fluency task in patients with major depressive disorder.Journal of Affective Disorders, 181, 9-17.
[32] Quaresima, V., & Ferrari, M. (2019). Functional near-infrared spectroscopy (fNIRS) for assessing cerebral cortex function during human behavior in natural/social situations: A concise review.Organizational Research Methods, 22(1), 46-68.
[33] Reindl V., Gerloff C., Scharke W., & Konrad K. (2018). Brain-to-brain synchrony in parent-child dyads and the relationship with emotion regulation revealed by fNIRS-based hyperscanning. NeuroImage, 178, 493-502.
[34] Rock P. L., Roiser J. P., Riedel W. J., & Blackwell A. D. (2014). Cognitive impairment in depression: A systematic review and meta-analysis.Psychological Medicine, 44(10), 2029-2040.
[35] Roland P. E., Larsen B., Lassen N. A., & Skinhoj E. (1980). Supplementary motor area and other cortical areas in organization of voluntary movements in man.Journal of Neurophysiology, 43(1), 118-136.
[36] Takamura M., Okamoto Y., Okada G., Toki S., Yamamoto T., Yamamoto O., Jitsuiki H., Yokota N., Tamura T., Kurata A., Kaichi Y., Akiyama Y., Awai K., & Yamawaki S. (2016). Disrupted brain activation and deactivation pattern during semantic verbal fluency task in patients with major depression.Neuropsychobiology, 74(2), 69-77.
[37] Uemura K., Shimada H., Doi, T., Makizako, H., Park, H., & Suzuki, T. (2014). Depressive symptoms in older adults are associated with decreased cerebral oxygenation of the prefrontal cortex during a trail-making test. Archives of Gerontology and Geriatrics, 59#(2), 422-428.
[38] Vos T., Abajobir A. A., Abate K. H., Abbafati C., Abbas K. M., Abd-Allah F., Abdulkader R. S., Abdulle A. M., Abebo T. A., Abera S. F., Aboyans V., Abu-Raddad L. J., Ackerman I. N., Adamu A. A., Adetokunboh O., Afarideh M., Afshin A., Agarwal S. K., Aggarwal R., … Murray, C. J. L. (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016.The Lancet, 390(10100), 1211-1259.
[39] Zhang J. X., Zhang X. L., Yang G. Y., & Feng Z. Z. (2022). Impulsiveness indirectly affects suicidal ideation through depression and simultaneously moderates the indirect effect: A moderated mediation path model.Frontiers in Psychiatry, 13, 913680.
[40] Zhang Y., Li X., Guo Y., Zhang Z., Xu F., Xiang N., Qiu M., Xiao Q., Wang P., & Shi H. (2022). Dorsolateral prefrontal activation in emotional autobiographical task in depressed and anxious college students: An fNIRS study.International Journal of Environmental Research and Public Health, 19(21), 14335.
[41] Zheng M., Da H., Pan X., Bian Y., Li X., Xiao Q., Qiu M., Xiang N., Zhu D., Wei Q., & Zhang Y. (2023). Dorsolateral prefrontal activation in depressed young adults with and without suicidal ideation during an emotional autobiographical memory task: A fNIRS study.Journal of Affective Disorders, 326, 216-224. |
|
|
|
